THE ANIMAL CARE AND USE PROGRAM
RESEARCH INVOLVING ANIMAL SUBJECTS
Animal Care & Use Committee | Principal
Investigators / Staff |
| Clinical Veterinarians
| University Administration
Care & Use Committee
The IACUC oversees all animal research and
instruction at UCSF in order to ensure the ethical, regulatory,
mandates governing the use of animals in research and instruction
are met. The Committee is comprised of at least 12 members,
including at least one representative of the public, whose
expertise and experience qualify them to oversee UCSF's animal
facilities, and procedures. The Committee's charge is to:
• Review and approve the animal welfare
aspects of all research and instruction at UCSF;
• Review UCSF's program for humane care and use of animals
• Conduct semi-annual inspections on all UCSF animal facilities;
• Prepare and submit reports of its evaluations to the
• Make recommendations to the Vice Chancellor for Research
regarding any aspect of UCSF's animal program, facilities, or
• Suspend any activity involving animals, which is in
violation of applicable regulations, policies, or procedures
of an approved protocol.
Before initiating, modifying, or renewing any
research project that uses animal subjects, Principal Investigators
must submit an application to the Committee on Animals Research
(IACUC) for review and approval. Principal investigators are also
responsible for renewing their IACUC approvals on a yearly basis.
Principal investigators are responsible for
assuring that everyone under their supervision involved in the
care and use of laboratory animals is properly
is thoroughly knowledgeable about the details of the approved
protocol , understands his or her obligation to comply with all
applicable regulations and federal and institutional policies,
and has signed the
Personnel Signature Page.
Anyone who witnesses or has reliable information
about non-compliance with a IACUC-approved protocol or an incident
of mistreatment of animals should notify the Laboratory Animal
Resource Center (LARC) veterinary staff or Director, the Institutional Animal Care & Use Committee, or the office of the Executive Vice Chancellor.
To report incidents of non-compliance or
mistreatment of animals, call the LARC at 476-1571, or the
at 476-2197, or the Executive Vice Chancellor at 502-5677, or
refer to the information on this website: IACUC
Policy on Report and Follow-up of Animal Care and Use Concerns.
Clinical veterinarians are responsible for:
• the prevention, diagnosis, and treatment
of disease in laboratory animals;
• advising investigators regarding the use of models for
research projects, proper anesthetic techniques, and control
of animal and human pathogens;
• conducting training programs for investigators, staff,
and students in the proper care and use of animals.
• Reporting to the IACUC any serious or ongoing concerns
regarding the care and use of animals.
Clinical veterinarians are authorized to terminate
immediately any activity that is out of compliance with approved
or accepted procedures or that poses an imminent threat to the
welfare of a laboratory animal.
To inquire about acquisition, housing, or
veterinary care of animals, or training in or assistance with
experimental techniques, including anesthesia and analgesia, or
for consultation in the planning of an experiment, call the Laboratory
Animal Resource Center at 476-2204. You may also consult the LARC
The Executive Vice Chancellor must assure the
federal government on an annual basis that UCSF is in compliance
with all provisions of the Animal Welfare Act, the NIH Guide for
the Care and Use of Laboratory Animals, and the PHS Policy on
the Humane Care and Use of Laboratory Animals.
Through the Laboratory Animal Resource Center
(LARC), UCSF provides administrative services for ordering, husbandry,
and veterinary care for all animals, and an occupational health
program for personnel who work in laboratory animal facilities
or have frequent contact with laboratory animals.
University administration provides the resources
to support the activities of the IACUC, maintain necessary records,
and report as required on the status of the animal care and use
program and the membership of the Institutional Animal Care & Use Committee.
The University provides legal protection for
members of the Institutional Animal Care & Use Committee and to principal investigators
granted approval to conduct such research who have met their obligations
in good faith.
The Institutional Official (IO) must report
to the NIH's Office of Laboratory Animal Welfare (OLAW) and the
Animal Care section of the United States Department of Agriculture
on the circumstances and actions taken in respect to:
• any serious or continuing protocol
• any serious deviations from the provisions in the
Guide for the Care and Use of Laboratory Animals; or
• suspension of any activity by the Institutional Animal Care & Use Committee.
UCSF grants whistle-blowing protection to anyone
who reports protocol violations or other acts of noncompliance.
Under the provisions of Freedom of Information
Act and the California Public Records Act, the University is required,
upon request, to release to the public details of any specific,
funded research project.