UCSF Guidelines on Reconstituting Non-Pharmaceutical Grade Compounds (Posted June 2008)
In compliance with the NIH and USDA regulations, non-pharmaceutical grade drugs are to be used in live animals only when there is no pharmaceutical grade alternative available. If there is a scientific need to use non-pharmaceutical grade compounds, the following guidelines should be followed:
- Compounds must be sterilized prior to administration. The reconstituted compound may be sterilized by passing through a 0.2 μm filter. Solvents used for reconstitution should be pharmaceutical grade if possible.
- Reconstituted compounds must be labeled identifying the compound, the date of preparation and the expiration date (if applicable).
- Reconstituted compounds should be discarded before degradation occurs. If degradation period is unknown, prepare compound fresh for each use.
- Follow all manufacturer guidelines.