UCSF home page UCSF home page About UCSF Search UCSF UCSF Medical Center
UCSF navigation bar
AWBanner
Alternatives to the Use of Animals in Research
Species-Specific Information & Drug Formulary
Standard Procedures & Guidelines
Policies & Regulations
Animal Care & Use Program
How to Apply to the IACUC
Frequently Asked Questions
Forms
Report an Animal Welfare Concern
Animal Research & Care
Laboratory Animal Resource Center(LARC)
Training Program
Working Safely with Animals
RIO
THE INSTITUTIONAL ANIMAL CARE AND USE COMMITTEE (IACUC)

UCSF Guidelines on Reconstituting Non-Pharmaceutical Grade Compounds (Posted June 2008)

In compliance with the NIH and USDA regulations, non-pharmaceutical grade drugs are to be used in live animals only when there is no pharmaceutical grade alternative available. If there is a scientific need to use non-pharmaceutical grade compounds, the following guidelines should be followed:

  • Compounds must be sterilized prior to administration. The reconstituted compound may be sterilized by passing through a 0.2 μm filter. Solvents used for reconstitution should be pharmaceutical grade if possible.
  • Reconstituted compounds must be labeled identifying the compound, the date of preparation and the expiration date (if applicable).
  • Reconstituted compounds should be discarded before degradation occurs. If degradation period is unknown, prepare compound fresh for each use.
  • Follow all manufacturer guidelines.