Resources for Experimental Design and Sample Size Determination

To assist principal investigators and animal users in designing their animal experiments and determining sample sizes for any given experiment, we encourage you to access the following links:

Experimental design hub – National Centre for the 3Rs (NC3Rs) (UK)

The Experimental Design Assistant, an online tool from the NC3Rs  

Book: The Design and Statistical Analysis of Animal Experiments by Simon T. Bate and Robin A. Clark (book review)

InVivoStat, a statistical software package (using the R statistics engine)

Paper: The Design and Statistical Analysis of Animal Experiments: Introduction to this Issue (pdf) (Festing and Nevalainen, 2014)

Blog post from the NC3Rs: How to decide your sample size when the power calculation is not straightforward

Sample Size Calculators recommended by UCSF’s Clinical and Translational Science Institute

UCSF IACUC Recommended Animal Numbers Spreadsheet