Slides

IACUC PROTOCOL RENEWAL
SUBMISSION GUIDE

Progress Report (Renewal Section)

There will be a progress report to discuss completed/continuing work and the general progress the lab has made over the previous three-year period.

Please ensure this is completed in full, emphasizing experiments completed, publications, etc. Plan ahead, as the average review time is 10-12 weeks.

Renewal Process Checklist

Renewal checklist
SECTIONWHAT TO REVIEW / UPDATE
Objectives of
Proposed Research		Review and possibly update to reflect current work.
A. Funding

Verify funding is current. Any new federal funding would require you to upload the following to the documents section in RIO.

  • Vertebrate Animal Section (VAS)
  • Research Strategy Section (RSS)
  • Grant Award Letter (Full Cover Page)
  • Contact the IACUC office before submitting a DoW-funded renewal.
C. Animals

Confirm the number of animals needed for the next three-year period.

  • Confirm experiments removed from C (if applicable) are removed elsewhere in the protocol (procedures, agents, adverse effects).
D. Contacts &
Personnel		Verify training is up to date, lab personnel are current, and the “Direct 24hr Cell” field for all animal users is completed to comply with the new requirement.
E.1. Justifications &
Alternatives		Update to the most current year and include any new literature searches.
G–J. Procedures &
Related Sections		Remove experiments from C (if applicable) from these sections elsewhere in the protocol (procedures, surgery, agents, adverse effects). Update all applicable sections (G, H, I, J) if adding new procedures.
K. LocationsConfirm if you plan on performing animal work in different areas.
P. Tissue Sharing &
Live Animal Disposition		Ensure this is up to date.

During Review & If Expired

The lab may continue to perform animal experiments under the active protocol while the renewal is under review.

However, if the protocol expires, all non-essential animal work would be required to stop. The lab should discuss plans to address any currently active or upcoming studies as well as breeding animals, which may be maintained as described in the FAQ.

Animal Care During Expiration

Upon expiration, protocols are automatically transferred to the LARC holding protocol. The following animal care activities may continue.

  1. PI feeding or watering animals (e.g., antibiotic feed or water, special diets)
  2. Medications, including antibiotics and analgesics
  3. Visually observing animals for pain, distress, or ill health (e.g., seizures)
  4. Measurements needed to evaluate health status (e.g., blood glucose, measuring tumor size)
  5. Maintenance of implants or other medical devices

IACUC Protocol Submission

Submit and manage your protocol in RIO: https://rio.ucsf.edu

Questions?

Please reach out to the IACUC office with any questions or concerns! [email protected]; 415-476-2197